Protein tyrosine kinase p56-Lck regulates lymphocyte function- associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell [published erratum appears in J Exp Med 1995 Jan 1;181(1):442]

@article{Torigoe1994ProteinTK,
  title={Protein tyrosine kinase p56-Lck regulates lymphocyte function- associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell [published erratum appears in J Exp Med 1995 Jan 1;181(1):442]},
  author={Toshihiko Torigoe and Juan Manuel Arg{\"u}elles San Mill{\'a}n and Koon Wing Chan and Russell S. Taichman and A. Larsan Aro Brian and John C. Reed and R Tachman R corrected to Taichman},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={1115 - 1127}
}
Elevated levels of p56-Lck kinase activity were achieved in an interleukin 2 (IL-2)-dependent cloned cytolytic T cell CTLL-2 through gene transfer approaches. CTLL-2-Lck cells remained dependent on IL-2 for growth and survival in culture but exhibited markedly elevated, IL-2-independent cytolytic activity against a variety of tumor targets. This immune cell effector function was similar to the non-major histocompatibility complex-restricted cytolytic activity previously described for lymphokine… CONTINUE READING