Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling

@article{Dikic1999ProteinTK,
  title={Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling},
  author={Ivan Dikic and Andree Blaukat},
  journal={Cell Biochemistry and Biophysics},
  year={1999},
  volume={30},
  pages={369-387}
}
Abundant evidence has indicated that protein tyrosine kinases (PTKs) convey signals from G protein-coupled receptors (GPCRs) to regulate cell proliferation, migration, adhesion, and potentialy cellular transformation. Molecular mechanisms by which PTKs regulate such diverse effects in GPCR signaling are not well understood. Recently, an unifying theme has emerged where both growth factors and GPCRs utilize protein tyrosine kinase activity and the highly conserved Ras/MAP kinase pathway to… CONTINUE READING
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