Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

@article{Lev1995ProteinTK,
  title={Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions},
  author={Sima Lev and Herman Moreno and Rhysly Martinez and P D Canoll and Elior Peles and Jos{\'e} M. Musacchio and Gregory D. Plowman and Bernardo Rudy and Joseph Schlessinger},
  journal={Nature},
  year={1995},
  volume={376},
  pages={737-745}
}
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in… 

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