Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

@article{Lev1995ProteinTK,
  title={Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions},
  author={Sima Lev and Horacio Moreno and Rodrigo Mart{\'i}nez and Peter Canoll and Elior Peles and Jos{\'e} M. Musacchio and Gregory D. Plowman and Bernardo Rudy and Joseph Schlessinger},
  journal={Nature},
  year={1995},
  volume={376},
  pages={737-745}
}
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in… CONTINUE READING
Highly Influential
This paper has highly influenced 65 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 388 extracted citations

CF airway smooth muscle transcriptome reveals a role for PYK2.

JCI insight • 2017
View 4 Excerpts
Highly Influenced

Physiology and pathology of endothelin-1 in renal mesangium.

American journal of physiology. Renal physiology • 2003
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…