Protein turnover in insulin-treated, alloxan-diabetic lean and obese Zucker rats.

@article{Chan1985ProteinTI,
  title={Protein turnover in insulin-treated, alloxan-diabetic lean and obese Zucker rats.},
  author={C P-Y Chan and Robert J. Hansen and Judith S. Stern},
  journal={The Journal of nutrition},
  year={1985},
  volume={115 8},
  pages={
          959-69
        }
}
Obese and lean Zucker rats were made diabetic by intracardiac injections of alloxan (65-72 mg/kg body weight) and then given daily injections of protamine zinc insulin [1.25 U/(100 g/d)] for 6, 9 and 12 d. Body weight, food intake, plasma glucose and immunoreactive insulin concentrations were not different for lean and obese diabetic rats of similar ages. Rates of increase in carcass protein, mixed muscle protein and myofibrillar protein were less in obese than in lean rats. However, rates of… CONTINUE READING