Protein turnover in acute and chronic liver disease.

  title={Protein turnover in acute and chronic liver disease.},
  author={Stephen J D O'keefe and Ralph R. Abraham and Myesha Davis and Roger Williams},
  journal={Acta chirurgica Scandinavica. Supplementum},
The method of constant infusion of U14C tyrosine tracer was used to measure whole body protein turnover in 24 patients with liver disease of varying severity. Whilst on a basic diet of glucose alone (5 g/hr), protein turnover and endogenous breakdown was significantly elevated in patients with cirrhosis and fulminant hepatic failure (F.H.F.), breakdown rising to 700 g/d greater than normal in F.H.F. In addition plasma aromatic aminoacids were significantly elevated and positively associated… CONTINUE READING

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