Protein transport across the endoplasmic reticulum membrane.

@article{Rapoport2008ProteinTA,
  title={Protein transport across the endoplasmic reticulum membrane.},
  author={Tom A Rapoport},
  journal={The FEBS journal},
  year={2008},
  volume={275 18},
  pages={4471-8}
}
A decisive step in the biosynthesis of many eukaryotic proteins is their partial or complete translocation across the endoplasmic reticulum membrane. A similar process occurs in prokaryotes, except that proteins are transported across or are integrated into the plasma membrane. In both cases, translocation occurs through a protein-conducting channel that is formed from a conserved, heterotrimeric membrane protein complex, the Sec61 or SecY complex. Structural and biochemical data suggest… CONTINUE READING
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