Protein translocation as a tool: The current rapamycin story.

@article{Putyrski2012ProteinTA,
  title={Protein translocation as a tool: The current rapamycin story.},
  author={Mateusz Putyrski and Carsten Schultz},
  journal={FEBS letters},
  year={2012},
  volume={586 15},
  pages={2097-105}
}
In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science. 
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Controlling Protein–Protein Interactions Using Chemical Inducers and Disrupters of Dimerization in: Chemical Biology. From Small Molecules to Systems Biology and Drug Design (Schreiber

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