Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

@article{Harding1999ProteinTA,
  title={Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase},
  author={Heather P Harding and Yuhong Zhang and David Ron},
  journal={Nature},
  year={1999},
  volume={397},
  pages={271-274}
}
Protein synthesis and the folding of the newly synthesized proteins into the correct three-dimensional structure are coupled in cellular compartments of the exocytosis pathway by a process that modulates the phosphorylation level of eukaryotic initiation factor-2α (eIF2α) in response to a stress signal from the endoplasmic reticulum (ER),. Activation of this process leads to reduced rates of initiation of protein translation during ER stress. Here we describe the cloning of perk, a gene… CONTINUE READING
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