Protein transfer across microsomal membranes reassembled from separated membrane components

@article{Warren1978ProteinTA,
  title={Protein transfer across microsomal membranes reassembled from separated membrane components},
  author={Graham Warren and Bernhard Dobberstein},
  journal={Nature},
  year={1978},
  volume={273},
  pages={569-571}
}
THE synthesis of secretory proteins is initiated on ribosomes in the cell cytoplasm and the first part of the polypeptide chain to appear is a short sequence termed the signal sequence1. This signal is thought to direct the ribosomal complex to the endoplasmic reticulum (ER) membrane where the synthesis of the rest of the secretory protein is tightly… CONTINUE READING