Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells.

@article{TskvitariaFuller2007ProteinTA,
  title={Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells.},
  author={Irina Tskvitaria-Fuller and Neeta Mistry and Shining Sun and Christoph W{\"u}lfing},
  journal={Journal of immunological methods},
  year={2007},
  volume={319 1-2},
  pages={64-78}
}
The Rho family GTPase Cdc42 is a critical regulator of cellular polarization from yeast to man. An analysis of its function in T cell activation is therefore of interest. This analysis poses two substantial challenges, similar to the analysis of many other critical T cell signaling intermediates. First, Cdc42 is required for development and cell survival, necessitating short-term manipulation of its activity. Second, Cdc42 is likely involved in multiple signaling pathways, requiring approaches… CONTINUE READING

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