Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+‐dependent action of a multifunctional protein

@article{Kirly2011ProteinTB,
  title={Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+‐dependent action of a multifunctional protein},
  author={R{\'o}bert Kir{\'a}ly and M{\'a}t{\'e} A Dem{\'e}ny and L{\'a}szl{\'o} F{\'e}s{\"u}s},
  journal={The FEBS Journal},
  year={2011},
  volume={278}
}
Transglutaminase 2 (TG2) is the first described cellular member of an enzyme family catalyzing Ca2+‐dependent transamidation of proteins. During the last two decades its additional enzymatic (GTP binding and hydrolysis, protein disulfide isomerase, protein kinase) and non‐enzymatic (multiple interactions in protein scaffolds) activities, which do not require Ca2+, have been recognized. It became a prevailing view that TG2 is silent as a transamidase, except in extreme stress conditions, in the… Expand
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TLDR
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