Protein titration in the crystal state.

@article{Berisio1999ProteinTI,
  title={Protein titration in the crystal state.},
  author={Rita Berisio and Victor S. Lamzin and Filomena Sica and Keith S Wilson and Adriana Zagari and Lelio Mazzarella},
  journal={Journal of molecular biology},
  year={1999},
  volume={292 4},
  pages={845-54}
}
Proteins are complex structures whose overall stability critically depends on a delicate balance of numerous interactions of similar strength, which are markedly influenced by their environment. Here, we present an analysis of the effect of pH on a protein structure in the crystalline state using RNase A as a model system. By altering only one physico-chemical parameter in a controlled manner, we are able to quantify the structural changes induced in the protein. Atomic resolution X-ray… CONTINUE READING

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