Protein targeting to the malaria parasite plastid.

@article{Tonkin2007ProteinTT,
  title={Protein targeting to the malaria parasite plastid.},
  author={Christopher J. Tonkin and Ming Kalanon and Geoffrey Ian McFadden},
  journal={Traffic},
  year={2007},
  volume={9 2},
  pages={
          166-75
        }
}
The relict plastid, or apicoplast, of the malaria parasite Plasmodium falciparum is an essential organelle and a promising drug target. Most apicoplast proteins are nuclear encoded and post-translationally targeted into the organelle using a bipartite N-terminal extension, consisting of a typical endomembrane signal peptide and a plant-like transit peptide. Apicoplast protein targeting commences through the parasite's secretory pathway. We review recent experimental evidence suggesting that the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

Der1-mediated preprotein import into the periplastid compartment of chromalveolates?

  • Molecular biology and evolution
  • 2007
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme

GG van Dooren, V Su, MC D’Ombrain, GI. McFadden
  • J Biol Chem
  • 2002
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast

PonpuakM, KlembaM, +3 authors DE Goldberg
  • Mol Microbiol
  • 2007
VIEW 3 EXCERPTS

Similar Papers

Loading similar papers…