Protein targeting to endosomes and phagosomes via FYVE and PX domains.

@article{Birkeland2004ProteinTT,
  title={Protein targeting to endosomes and phagosomes via FYVE and PX domains.},
  author={Hanne C G Birkeland and Harald Stenmark},
  journal={Current topics in microbiology and immunology},
  year={2004},
  volume={282},
  pages={
          89-115
        }
}
Phosphatidylinositol 3-phosphate (PI3P) is generated on early endosomal and phagosomal membranes by PI 3-kinases. This lipid serves important regulatory functions in phagocytosis, endocytic traffic, receptor signalling and microbial killing through the recruitment and activation of a number of effector proteins. Almost all of these effectors contain FYVE or PX domains, functional protein modules which are conserved from yeast to mammals. Structural information is available regarding the binding… CONTINUE READING
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