Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

@article{Cannon1991ProteinSR,
  title={Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport},
  author={Julian V. Cannon and David Philip Lane},
  journal={Nature},
  year={1991},
  volume={349},
  pages={802-806}
}
THE p53 protein is rendered temperature-sensitive by a point mutation1. Rat cells transformed by this mutant p53 and an activated ras oncogene grow well at 37°C but cease DNA synthesis and cell division when shifted to 32°C (ref. 1). Immunostaining demonstrates that the mutant p53 protein is in the nucleus of the arrested cells at 32°C but in the cytoplasm of the growing cells at 37°C. This is the first example of a protein which is temperature-sensitive for nuclear transport. The translocation… CONTINUE READING

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