Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons.

@article{VivancoDomnguez2012ProteinSF,
  title={Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons.},
  author={Seraf{\'i}n Vivanco-Dom{\'i}nguez and Jos{\'e} G Bueno-Mart{\'i}nez and Gloria Le{\'o}n-Avila and Nobuhiro Iwakura and Akira Kaji and H. Kaji and Gabriel Guarneros},
  journal={Journal of molecular biology},
  year={2012},
  volume={417 5},
  pages={425-39}
}
During translation, ribosomes stall on mRNA when the aminoacyl-tRNA to be read is not readily available. The stalled ribosomes are deleterious to the cell and should be rescued to maintain its viability. To investigate the contribution of some of the cellular translation factors on ribosome rescuing, we provoked stalling at AGA codons in mutants that affected the factors and then analyzed the accumulation of oligopeptidyl (peptides of up to 6 amino acid residues, oligopep-)-tRNA or polypeptidyl… CONTINUE READING

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