Protein sulfenic acids in redox signaling.

  title={Protein sulfenic acids in redox signaling.},
  author={Leslie B. Poole and P. Andrew Karplus and A. K. Claiborne},
  journal={Annual review of pharmacology and toxicology},
Reactive (low pKa) cysteine residues in proteins are critical components in redox signaling. A particularly reactive and versatile reversibly oxidized form of cysteine, the sulfenic acid (Cys-SOH), has important roles as a catalytic center in enzymes and as a sensor of oxidative and nitrosative stress in enzymes and transcriptional regulators. Depending on environment, sometimes the sulfenic acid provides a metastable oxidized form, and other times it is a fleeting intermediate giving rise to… CONTINUE READING
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