Protein subunits released by surface collisions of noncovalent complexes: nativelike compact structures revealed by ion mobility mass spectrometry.

@article{Zhou2012ProteinSR,
  title={Protein subunits released by surface collisions of noncovalent complexes: nativelike compact structures revealed by ion mobility mass spectrometry.},
  author={Mowei Zhou and Shai Dagan and Vicki H. Wysocki},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 18},
  pages={4336-9}
}
The quaternary structure of proteins determines their biological function, and a majority of proteins exist as oligomers in vivo with miscellaneous architectures. Mass spectrometry (MS) can be applied to study the stoichiometry and interactions of protein complexes by molecular weight measurements under gentle instrumental conditions where noncovalent interactions are preserved in the gas phase. Recently, there have been extensive efforts to also utilize ion mobility (IM) techniques combined… CONTINUE READING