Protein structure prediction from sequence variation

@article{Marks2012ProteinSP,
  title={Protein structure prediction from sequence variation},
  author={Debora S. Marks and Thomas A. Hopf and Chris Sander},
  journal={Nature Biotechnology},
  year={2012},
  volume={30},
  pages={1072-1080}
}
Genomic sequences contain rich evolutionary information about functional constraints on macromolecules such as proteins. This information can be efficiently mined to detect evolutionary couplings between residues in proteins and address the long-standing challenge to compute protein three-dimensional structures from amino acid sequences. Substantial progress has recently been made on this problem owing to the explosive growth in available sequences and the application of global statistical… CONTINUE READING
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In addition to three - dimensional structure , the improved understanding of covariation may help identify functional residues involved in ligand binding , protein - complex formation and conformational changes .
In addition to three - dimensional structure , the improved understanding of covariation may help identify functional residues involved in ligand binding , protein - complex formation and conformational changes .
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