Protein structure determination in solution by two-dimensional and three-dimensional nuclear magnetic resonance spectroscopy.

@article{Gronenborn1990ProteinSD,
  title={Protein structure determination in solution by two-dimensional and three-dimensional nuclear magnetic resonance spectroscopy.},
  author={Angela M. Gronenborn and G Marius Clore},
  journal={Analytical chemistry},
  year={1990},
  volume={62 1},
  pages={2-15}
}
Over the last decade, nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful method for determining structures of biological macromolecules. This has opened a unique opportunity for obtaining high-resolution three-dimensional structures in solution, in contrast to the well-established methods of X-ray diffraction, which are applicable only to solids and in particular single crystals. This rapid development has been spurred by several key advances in the field, especially the… CONTINUE READING

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