Protein structure comparison by probability-based matching of secondary structure elements

  title={Protein structure comparison by probability-based matching of secondary structure elements},
  author={Edward S. C. Shih and Ming-Jing Hwang},
  volume={19 6},
MOTIVATION Protein structure comparison (PSC) has been used widely in studies of structural and functional genomics. However, PSC is computationally expensive and as a result almost all of the PSC methods currently in use look only for the optimal alignment and ignore many alternative alignments that are statistically significant and that may provide insight into protein evolution or folding. RESULTS We have developed a new PSC method with efficiency to detect potentially viable alternative… CONTINUE READING
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