Protein structure and the sequential structure of mRNA: alpha-helix and beta-sheet signals at the nucleotide level.

@article{Brunak1996ProteinSA,
  title={Protein structure and the sequential structure of mRNA: alpha-helix and beta-sheet signals at the nucleotide level.},
  author={S\oren Brunak and Jacob Engelbrecht},
  journal={Proteins},
  year={1996},
  volume={25 2},
  pages={237-52}
}
A direct comparison of experimentally determined protein structures and their corresponding protein coding mRNA sequences has been performed. We examine whether real world data support the hypothesis that clusters of rare codons correlate with the location of structural units in the resulting protein. The degeneracy of the genetic code allows for a biased selection of codons which may control the translational rate of the ribosome, and may thus in vivo have a catalyzing effect on the folding of… CONTINUE READING
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