Protein structure alignment using a genetic algorithm.

@article{Szustakowski2000ProteinSA,
  title={Protein structure alignment using a genetic algorithm.},
  author={Joseph D. Szustakowski and Zhiping Weng},
  journal={Proteins},
  year={2000},
  volume={38 4},
  pages={428-40}
}
We have developed a novel, fully automatic method for aligning the three-dimensional structures of two proteins. The basic approach is to first align the proteins' secondary structure elements and then extend the alignment to include any equivalent residues found in loops or turns. The initial secondary structure element alignment is determined by a genetic algorithm. After refinement of the secondary structure element alignment, the protein backbones are superposed and a search is performed to… CONTINUE READING

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