Protein structural alignment for detection of maximally conserved regions.

  title={Protein structural alignment for detection of maximally conserved regions.},
  author={Vladimir Kotlovyi and William Lee Nichols and Lynn F Ten Eyck},
  journal={Biophysical chemistry},
  volume={105 2-3},
An algorithm for comparison of homologous protein structures and for study of conformational changes in proteins, has been developed. The method is based on identification of pieces of the two molecules that have similar shapes, as determined by the local conformation of the polypeptide chain. Pieces that superpose within a specified tolerance are assembled into domains based on similar transformations for superposition. The result is sets of pieces that represent conserved structural elements… CONTINUE READING

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