Protein stabilization by cyclodextrins in the liquid and dried state.

@article{Serno2011ProteinSB,
  title={Protein stabilization by cyclodextrins in the liquid and dried state.},
  author={Tim Serno and Raimund Geidobler and Gerhard Winter},
  journal={Advanced drug delivery reviews},
  year={2011},
  volume={63 13},
  pages={1086-106}
}
Aggregation is arguably the biggest challenge for the development of stable formulations and robust manufacturing processes of therapeutic proteins. In search of novel excipients inhibiting protein aggregation, cyclodextrins and their derivatives have been under examination for use in parenteral protein products since more than 20 years and significant research work has been accomplished highlighting the great potential of cyclodextrins as stabilizers of therapeutic proteins. Oftentimes, the… CONTINUE READING

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