Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

  title={Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat},
  author={Viviana I. P{\'e}rez and Rochelle Buffenstein and V. Pragathi Masamsetti and Shanique Leonard and Adam B. Salmon and James Mele and Blazej Andziak and Ting Yang and Yael H. Edrey and Bertrand Friguet and Walter F. Ward and Arlan Richardson and Asish Ray Chaudhuri},
  journal={Proceedings of the National Academy of Sciences},
  pages={3059 - 3064}
The widely accepted oxidative stress theory of aging postulates that aging results from accumulation of oxidative damage. Surprisingly, data from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP) > 28.3 years], when compared with mice (MLSP 3.5 years) exhibit higher levels of lipid peroxidation, protein carbonylation, and DNA oxidative damage even at a young age. We hypothesize that age-related changes in protein structural stability, oxidation, and… 

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