Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

@article{Prez2009ProteinSA,
  title={Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat},
  author={V. P{\'e}rez and R. Buffenstein and V. Masamsetti and S. Leonard and A. Salmon and J. Mele and Blazej Andziak and Ting Yang and Yael H. Edrey and B. Friguet and W. Ward and Arlan Richardson and A. Chaudhuri},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={3059 - 3064}
}
The widely accepted oxidative stress theory of aging postulates that aging results from accumulation of oxidative damage. Surprisingly, data from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP) > 28.3 years], when compared with mice (MLSP 3.5 years) exhibit higher levels of lipid peroxidation, protein carbonylation, and DNA oxidative damage even at a young age. We hypothesize that age-related changes in protein structural stability, oxidation, and… Expand
Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach.
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Reports on the detection of higher level of oxidized protein carbonyls in the soluble cellular fractions of long-living rodent naked-mole rats compared to short-lived mice apparently contradicts a key tenet of the oxidative theory, suggesting that oxidative modification may not be the only criteria for impairment of protein and enzyme function. Expand
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TLDR
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