Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMb.

@article{Trk2000ProteinSA,
  title={Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMb.},
  author={Elisabeth Elena T{\"u}rk and J{\"u}rgen Schreiber and Michael Wegner},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 7},
  pages={4774-82}
}
The glial cells missing (GCM) family of transcription factors consists of Drosophila GCM and the mammalian proteins GCMa and GCMb. They are expressed in a highly restricted manner during development and are known or assumed to be important regulators of developmental fate decisions. As the biochemical properties of GCMb have not been studied so far, we have undertaken a detailed structure-function analysis of the mouse GCMb (mGCMb) protein. DNA-binding specificity was very similar to that of… CONTINUE READING

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