Protein-solvent interactions.

  title={Protein-solvent interactions.},
  author={N. R. V. Prabhu and Kim A. Sharp},
  journal={Chemical reviews},
  volume={106 5},
The central importance of solvent interactions in stabilization of specific protein structure has long been recognized. Decades ago, Tanford and Kirkwood treated in detail the interaction of charges with solvent, and they showed how desolvation/burial of charges upon protein folding was an important factor in stability. 1 The influence of their model, with further elaborations, can still be seen in much subsequent work on protein electrostatics and implicit solvent models. A little later… CONTINUE READING