Protein size and cerebrospinal fluid composition

@article{Felgenhauer2005ProteinSA,
  title={Protein size and cerebrospinal fluid composition},
  author={Klaus Felgenhauer},
  journal={Klinische Wochenschrift},
  year={2005},
  volume={52},
  pages={1158-1164}
}
  • K. Felgenhauer
  • Published 15 December 1974
  • Chemistry, Medicine
  • Klinische Wochenschrift
SummaryThe concentration ratios of several proteins between serum and cerebrospinal fluid (CSF) can be correlated more easily to hydrodynamic volumes than to molweights. Hydrodynamic radii were calculated from literature diffusion data and determined by analytical column chromatography and gel electrophoresis. Discrepancies between molweight and hydrodynamic volume become evident, especially with the high-molecular proteins because of stronger conformational variability in this size range. The… 
Low molecular solutes and the blood cerebrospinal fluid barrier
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The method described produces a quantitative differentiation between the locally synthesized and the serum-derived immunoglobulin fractions, which depends upon the hydrodynamic radii of the passively transferred molecules.
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  • H. Reiber
  • Biology
    Restorative neurology and neuroscience
  • 2003
TLDR
The review of the anatomical, physiological and biophysical knowledge points to the new interpretations: the changing albumin quotient is an indicator of changing CSF flow rate and not for a morphological "leakage" of the blood-brain barrier.
The Connected Steady State Model and the Interdependence of the CSF Proteome and CSF Flow Characteristics
TLDR
It is claimed that the biomarker potential of brain-derived proteins in CSF can be improved by considering individual subproteomic dynamics of the CSF system by critically reviewing existing experimental data and by reassessing their conformity to CSF flow assumptions.
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The results indicate that protein transfer across the blood/CSF barrier appears to be regulated by a molecular recognition mechanism that is probably saturable but may not be as specific for individual proteins as previously suggested.
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The ratio of albumin in cerebrospinal fluid (CSF) to serum may serve as an index of the integrity of the blood-CSF barrier, with increases in this ratio indicating increased permeability. The ratio
Cerebrospinal Fluid
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