Protein similarity search under mRNA structural constraints: application to targeted selenocysteine insertion.

@article{Backofen2002ProteinSS,
  title={Protein similarity search under mRNA structural constraints: application to targeted selenocysteine insertion.},
  author={Rolf Backofen and N. S. Narayanaswamy and Firas Swidan},
  journal={In silico biology},
  year={2002},
  volume={2 3},
  pages={275-90}
}
Selenocysteine is the 21th amino acid, which occurs in all kingdoms of life. Selenocysteine is encoded by the STOP-codon UGA. For its insertion, it requires a specific mRNA sequence downstream the UGA-codon that forms a hairpin like structure (called Sec insertion sequence (SECIS)). We consider the computational problem of generating new amino acid sequences containing selenocysteine. This requires to find an mRNA sequence that is similar to the SECIS-consensus, is able to form the secondary… CONTINUE READING

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