Protein signatures for survival and recurrence in metastatic melanoma.

  title={Protein signatures for survival and recurrence in metastatic melanoma.},
  author={William M Hardesty and Mark C. Kelley and Deming Mi and Robert L. Low and Richard M Caprioli},
  journal={Journal of proteomics},
  volume={74 7},
Patients with melanoma metastatic to regional lymph nodes exhibit a range in tumor progression, survival, and treatment. Current approaches to stratify patients with this stage of disease predominantly involve clinical and histological methods. Molecular classification thus far has focused almost exclusively on genetic mutations. In this study, proteomic data from 69 melanoma lymph node metastases and 17 disease free lymph nodes acquired by histology-directed MALDI imaging mass spectrometry… CONTINUE READING