Protein sequencing by mass analysis of polypeptide ladders after controlled protein hydrolysis

Abstract

The characterization of protein modifications is essential for the study of protein function using functional genomic and proteomic approaches. However, current techniques are not efficient in determining protein modifications. We report an approach for sequencing proteins and determining modifications with high speed, sensitivity and specificity. We… (More)
DOI: 10.1038/nbt1011

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