Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

@article{Hasegawa1992ProteinSA,
  title={Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.},
  author={Masanori Hasegawa and Maho Morishima-Kawashima and Koji Takio and Motoshi Suzuki and Koiti Titani and Yasuo Ihara},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 24},
  pages={17047-54}
}
Tau with unusually slow mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was purified from the Sarkosyl-insoluble pellet of Alzheimer's disease brain homogenates. Such species of tau (PHF-tau) are considered to construct the framework of the sodium dodecyl sulfate-soluble form of paired helical filaments (PHF). Detailed comparison of… CONTINUE READING