Protein self-association in solution: the bovine beta -lactoglobulin dimer and octamer.

  title={Protein self-association in solution: the bovine beta -lactoglobulin dimer and octamer.},
  author={Michael Gottschalk and Hanna Nilsson and Helena Roos and Bertil Halle},
  journal={Protein science : a publication of the Protein Society},
  volume={12 11},
We have used proton magnetic relaxation dispersion (MRD) to study the self-association of bovine beta-lactoglobulin variant A (BLG-A) as a function of temperature at pH 4.7 (dimer-octamer equilibrium) and as a function of NaCl concentration at pH 2.5 (monomer-dimer equilibrium). The MRD method identifies coexisting oligomers from their rotational correlation times and determines their relative populations from the associated dispersion amplitudes. From MRD-derived correlation times and… CONTINUE READING
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