Protein scaffolds in the coupling of synaptic exocytosis and endocytosis

  title={Protein scaffolds in the coupling of synaptic exocytosis and endocytosis},
  author={Volker Haucke and Erwin Neher and Stephan J. Sigrist},
  journal={Nature Reviews Neuroscience},
Mechanisms that ensure robust long-term performance of synaptic transmission over a wide range of activity are crucial for the integrity of neuronal networks, for processing sensory information and for the ability to learn and store memories. Recent experiments have revealed that such robust performance requires a tight coupling between exocytic vesicle fusion at defined release sites and endocytic retrieval of synaptic vesicle membranes. Distinct presynaptic scaffolding proteins are essential… CONTINUE READING
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