Protein scaffold and expression level determine antiviral activity of membrane-anchored antiviral peptides.

@article{Hermann2008ProteinSA,
  title={Protein scaffold and expression level determine antiviral activity of membrane-anchored antiviral peptides.},
  author={Felix G Hermann and Holger Martinius and Marc Egelhofer and Tsanan Giroglou and Torsten Tonn and Stefanie D Roth and Roland Zahn and Patricia Schult-Dietrich and Alexander Alexandrov and Ursula Dietrich and Christopher Baum and Dorothee von Laer},
  journal={Human gene therapy},
  year={2008},
  volume={20 4},
  pages={
          325-36
        }
}
Cell membrane-anchored (ma) antiviral peptides derived from the C-terminal heptad repeat of the HIV-1 transmembrane glycoprotein gp41 (C-peptides) and expressed from retroviral vectors were shown to efficiently inhibit HIV-1 entry into target cells. Here, we analyzed the influence of the vector backbone, the scaffold modules that anchor the peptide to the membrane and the length of the C-peptide on expression level and antiviral activity. In general, antiviral activity was determined primarily… CONTINUE READING