Protein restriction sequentially induces new urea transport processes in rat initial IMCD.

@article{Isozaki1994ProteinRS,
  title={Protein restriction sequentially induces new urea transport processes in rat initial IMCD.},
  author={Tetsuo Isozaki and Adrian G Gillin and Cheryl E. Swanson and Jeff M Sands},
  journal={The American journal of physiology},
  year={1994},
  volume={266 5 Pt 2},
  pages={F756-61}
}
We reported that feeding rats 8% protein for 4 wk induces two new urea transport processes in initial inner medullary collecting ducts (IMCD); neither is present in rats fed 18% protein. In this study, we measured the time course of induction of these transporters in perfused initial IMCD segments from rats fed 8% protein. Net urea flux was induced after 3 wk, whereas vasopressin-stimulated passive urea permeability (P(urea)) was induced after 2 wk. 8-Bromoadenosine 3',5'-cyclic monophosphate… CONTINUE READING