Protein rescue from aggregates by powerful molecular chaperone machines

@article{Doyle2013ProteinRF,
  title={Protein rescue from aggregates by powerful molecular chaperone machines},
  author={Shannon M. Doyle and Olivier Genest and Sue Wickner},
  journal={Nature Reviews Molecular Cell Biology},
  year={2013},
  volume={14},
  pages={617-629}
}
Protein quality control within the cell requires the interplay of many molecular chaperones and proteases. When this quality control system is disrupted, polypeptides follow pathways leading to misfolding, inactivity and aggregation. Among the repertoire of molecular chaperones are remarkable proteins that forcibly untangle protein aggregates, called disaggregases. Structural and biochemical studies have led to new insights into how these proteins collaborate with co-chaperones and utilize ATP… CONTINUE READING