Protein release behavior from porous microparticle with lysozyme/hyaluronate ionic complex.

@article{Lee2007ProteinRB,
  title={Protein release behavior from porous microparticle with lysozyme/hyaluronate ionic complex.},
  author={Eun Seong Lee and Min Kwon and Kun Na and Jun Ho Bae},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2007},
  volume={55 1},
  pages={125-30}
}
Porous microparticles (PMs) with a low density (<0.4 g/cm3) for pulmonary protein delivery were prepared by the water-in-oil-in-water (W1/O/W2) multi-emulsion method using a cyclodextrin derivative as a porogen. The complexation of positively charged lysozyme (Lys) and negative-charged hyaluronate (HA) was investigated for long-term protein release from PMs. The interaction of Lys and HA not only increased protein encapsulation efficiency but also stabilized Lys against a denaturing organic… CONTINUE READING

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