Protein refolding for industrial processes.

  title={Protein refolding for industrial processes.},
  author={Eliana D Clark},
  journal={Current opinion in biotechnology},
  volume={12 2},
Inclusion body refolding processes are poised to play a major role in the production of recombinant proteins. Improving renaturation yields by minimizing aggregation and reducing chemical costs are key to the industrial implementation of these processes. Recent developments include solubilization methods that do not rely on high denaturant concentrations and the use of high hydrostatic pressure for simultaneous solubilization and renaturation. 

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Continuous refolding of lysozyme with fed - batch addition of denatured protein solution

  • S Katoh, Y Katoh
  • Process Biochem
  • 2000

Effects of operating parameters in in vitro renaturation of a fusion protein of human growth hormone and glutathione S - transferase from inclusion body

  • CS Kim, EK Lee
  • Process Biochem
  • 2000

High pressure refolding of protein aggregates and inclusion bodies

  • T Randolph, J Carpenter, R StJohn
  • International application
  • 2000

Method for solubilization and naturation of somatotropins

  • SB Storrs, JS Tou, JM Ballinger
  • US patent
  • 2000

Process for the preparation of active somatotropin from inclusion bodies

  • Y Lee, H Lee, K Han
  • International application
  • 2000

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