Protein refolding for industrial processes.

  title={Protein refolding for industrial processes.},
  author={E. D. Clark},
  journal={Current opinion in biotechnology},
  volume={12 2},
  • E. D. Clark
  • Published 2001
  • Chemistry, Medicine
  • Current opinion in biotechnology
  • Inclusion body refolding processes are poised to play a major role in the production of recombinant proteins. Improving renaturation yields by minimizing aggregation and reducing chemical costs are key to the industrial implementation of these processes. Recent developments include solubilization methods that do not rely on high denaturant concentrations and the use of high hydrostatic pressure for simultaneous solubilization and renaturation. 
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