Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

@inproceedings{Wani2014ProteinRC,
  title={Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology},
  author={Revati Wani and Asako Nagata and Brion William Murray},
  booktitle={Front. Pharmacol.},
  year={2014}
}
The perception of reactive oxygen species has evolved over the past decade from agents of cellular damage to secondary messengers which modify signaling proteins in physiology and the disease state (e.g., cancer). New protein targets of specific oxidation are rapidly being identified. One emerging class of redox modification occurs to the thiol side chain of cysteine residues which can produce multiple chemically distinct alterations to the protein (e.g., sulfenic/sulfinic/sulfonic acid… CONTINUE READING
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