Protein quality control: triage by chaperones and proteases.

  title={Protein quality control: triage by chaperones and proteases.},
  author={Susan Gottesman and Sue Wickner and Michael R. Maurizi},
  journal={Genes & development},
  volume={11 7},
Proteases and chaperones together serve to maintain quahty control of cellular proteins. Both types of en­ zymes have as their substrates the variety of misfolded and partially folded proteins that arise from slow rates of folding or assembly, chemical or thermal stress, intrinsic structural instability, and biosynthetic errors. The pri­ mary function of classical chaperones, such as the Esch­ erichia coh DnaK/Hsp70 and its cochaperones, DnaJ and GrpE, and GroEL/Hsp60 and its cochaperone, GroES… CONTINUE READING

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