Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.

@article{Buckley2000ProteinproteinRH,
  title={Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.},
  author={Patrick A Buckley and J Baz Jackson and Thorsten Schneider and Scott A White and David W. Rice and Patrick J Baker},
  journal={Structure},
  year={2000},
  volume={8 8},
  pages={809-15}
}
BACKGROUND Membrane-bound ion pumps are involved in metabolic regulation, osmoregulation, cell signalling, nerve transmission and energy transduction. How the ion electrochemical gradient interacts with the scalar chemistry and how the catalytic machinery is gated to ensure high coupling efficiency are fundamental to the mechanism of action of such pumps. Transhydrogenase is a conformationally coupled proton pump linking a proton gradient to the redox reaction between NAD(H) and NADP(H). The… CONTINUE READING