Protein-protein interfaces: architectures and interactions in protein-protein interfaces and in protein cores. Their similarities and differences.

@article{Tsai1996ProteinproteinIA,
  title={Protein-protein interfaces: architectures and interactions in protein-protein interfaces and in protein cores. Their similarities and differences.},
  author={C. J. Tsai and Shoei Loong Lin and Haim J. Wolfson and Ruth Nussinov},
  journal={Critical reviews in biochemistry and molecular biology},
  year={1996},
  volume={31 2},
  pages={127-52}
}
Protein structures generally consist of favorable folding motifs formed by specific arrangements of secondary structure elements. Similar architectures can be adopted by different amino acids sequences, although the details of the structures vary. It has long been known that despite the sequence variability, there is a striking preferential conservation of the hydrophobic character of the amino acids at the buried positions of these folding motifs. Differences in the sizes of the side-chains… CONTINUE READING