Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

@article{Raijmakers2002ProteinproteinIB,
  title={Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.},
  author={R. A. P. Raijmakers and W. T. M. Vree Egberts and Walther J. van Venrooij and Ger J. M. Pruijn},
  journal={Journal of molecular biology},
  year={2002},
  volume={323 4},
  pages={653-63}
}
The exosome is a complex of 3'-->5' exoribonucleases, which functions in a variety of cellular processes, all requiring the processing or degradation of RNA. Here we present a model for the assembly of the six human RNase PH-like exosome subunits into a hexameric ring structure. In part, this structure is on the basis of the evolutionarily related bacterial degradosome, the core of which consists of three copies of the PNPase protein, each containing two RNase PH domains. In our model three… CONTINUE READING

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