Protein-protein docking with backbone flexibility.

  title={Protein-protein docking with backbone flexibility.},
  author={Chu Wang and Philip G. Bradley and David Baker},
  journal={Journal of molecular biology},
  volume={373 2},
Computational protein-protein docking methods currently can create models with atomic accuracy for protein complexes provided that the conformational changes upon association are restricted to the side chains. However, it remains very challenging to account for backbone conformational changes during docking, and most current methods inherently keep monomer backbones rigid for algorithmic simplicity and computational efficiency. Here we present a reformulation of the Rosetta docking method that… CONTINUE READING
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