Protein-protein docking: is the glass half-full or half-empty?

@article{Vajda2004ProteinproteinDI,
  title={Protein-protein docking: is the glass half-full or half-empty?},
  author={Sandor Vajda and Carlos J. Camacho},
  journal={Trends in biotechnology},
  year={2004},
  volume={22 3},
  pages={110-6}
}
Are current docking methods capable of building complexes from putative component protein structures? Results of recent computational studies, including those of the CAPRI (Critical Assessment of Protein Interactions) competition, were used to determine the key properties for successful docking and introduce a classification of protein complexes based on docking difficulty. Enzyme-inhibitor complexes could be determined with reasonable accuracy - possibly to within a few alternative structures… CONTINUE READING

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