Protein-protein binding affinity prediction on a diverse set of structures

@article{Moal2011ProteinproteinBA,
  title={Protein-protein binding affinity prediction on a diverse set of structures},
  author={Iain H. Moal and Rudi Agius and Paul A. Bates},
  journal={Bioinformatics},
  year={2011},
  volume={27 21},
  pages={
          3002-9
        }
}
MOTIVATION Accurate binding free energy functions for protein-protein interactions are imperative for a wide range of purposes. Their construction is predicated upon ascertaining the factors that influence binding and their relative importance. A recent benchmark of binding affinities has allowed, for the first time, the evaluation and construction of binding free energy models using a diverse set of complexes, and a systematic assessment of our ability to model the energetics of conformational… CONTINUE READING

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