Protein prenylation: from discovery to prospects for cancer treatment.

  title={Protein prenylation: from discovery to prospects for cancer treatment.},
  author={Michael H Gelb and Jeff D. Scholten and Judith S. Sebolt-Leopold},
  journal={Current opinion in chemical biology},
  volume={2 1},
A specific set of proteins in eukaryotic cells contain covalently attached carboxy-terminal prenyl groups (15-carbon farnesyl and 20-carbon geranylgeranyl). Many of them are signaling proteins including Ras, heterotrimeric G proteins and Rab proteins. The protein prenyltransferases which attach prenyl groups to proteins have been well characterized, and an X-ray structure is available for protein farnesyltransferase. Inhibitors of protein farnesyltransferase are showing sufficient promise in… CONTINUE READING