Protein posttranslational modifications: the chemistry of proteome diversifications.

@article{Walsh2005ProteinPM,
  title={Protein posttranslational modifications: the chemistry of proteome diversifications.},
  author={C. Walsh and Sylvie Garneau-Tsodikova and G. Gatto},
  journal={Angewandte Chemie},
  year={2005},
  volume={44 45},
  pages={
          7342-72
        }
}
  • C. Walsh, Sylvie Garneau-Tsodikova, G. Gatto
  • Published 2005
  • Chemistry, Medicine
  • Angewandte Chemie
  • The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the number of proteins predicted by DNA coding capacities owing to directed posttranslational modifications. Enzymes dedicated to such protein modifications include 500 human protein kinases, 150 protein phosphatases, and 500 proteases. The major types of protein covalent modifications, such as phosphorylation, acetylation, glycosylation, methylation, and ubiquitylation, can be classified according to the type… CONTINUE READING
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