Protein posttranslational modifications: the chemistry of proteome diversifications.

  title={Protein posttranslational modifications: the chemistry of proteome diversifications.},
  author={C. Walsh and Sylvie Garneau-Tsodikova and G. Gatto},
  journal={Angewandte Chemie},
  volume={44 45},
  • C. Walsh, Sylvie Garneau-Tsodikova, G. Gatto
  • Published 2005
  • Chemistry, Medicine
  • Angewandte Chemie
  • The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the number of proteins predicted by DNA coding capacities owing to directed posttranslational modifications. Enzymes dedicated to such protein modifications include 500 human protein kinases, 150 protein phosphatases, and 500 proteases. The major types of protein covalent modifications, such as phosphorylation, acetylation, glycosylation, methylation, and ubiquitylation, can be classified according to the type… CONTINUE READING
    734 Citations
    Synthesis of lipidated peptides.
    • 3
    Unique modifications of translation elongation factors
    • 43
    Enzymatic Glycosylation of Peptide Arrays on Gold Surfaces
    • 55
    Protein TAILS: when termini tell tales of proteolysis and function.
    • 61
    Chemical and semisynthesis of posttranslationally modified proteins.
    • 34
    • PDF


    Proteomic analysis of post-translational modifications
    • 1,423
    • PDF
    Protein C-mannosylation: facts and questions.
    • 110
    • PDF
    Protein prenylation: molecular mechanisms and functional consequences.
    • 1,880
    Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.
    • K. Wilkinson
    • Biology, Medicine
    • Seminars in cell & developmental biology
    • 2000
    • 541
    Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae
    • 1,463
    Protein splicing and related forms of protein autoprocessing.
    • H. Paulus
    • Biology, Medicine
    • Annual review of biochemistry
    • 2000
    • 405
    Molecular Machines for Protein Degradation
    • 186
    Dissecting the Chemistry of Protein Splicing and Its Applications.
    • 242
    Roles of N-linked glycans in the endoplasmic reticulum.
    • 1,737